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This allowed yet another layer of replication.
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We found that positive- and negative-sense RNA measurements made across multiple MOIs, along with quantitative data on virion packaging, are sufficient to infer that poliovirus replication occurs in several layers of intermediate replication, in contrast to the oft-assumed 'stamping machine' model.
Storage layer takes care of replication of data and fault tolerance.
The ultrathin nature of titania layer enabled faithful replication of the nanoscopic structural details of both the template substances.
Initial infection with HPV is understood to occur in the basal layer of the epithelium, and productive replication is tied to cell differentiation/maturation.
This would agree with the more punctuated nuclear pattern of PCNA in suprabasal layers, possibly due to a lower number of replication origins.
We suggest that regulation of replication timing by Tel1 adds another layer to the regulation of telomerase at endogenous telomeres.
The virus infects cells in the basal layer of stratified squamous epithelia and viral replication shows both temporal and spatial regulation of viral protein expression.
This question arises as new 'c-Myc naïve' keratinocytes are likely to have entered the suprabasal compartment as a result of on-going basal layer replication during the transient period of c-Myc inactivation.
Hence the difficulty of replication.
How about extending the notion of replication?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com