In juvenile, adult, and pregnant females, however, β-gal expression was primarily seen in cells residing within the basal epithelial cell layer of mammary glands (Fig. 1B).
In contrast to the intense expression seen in the basal cell layer of benign glands, a complete loss of S100A6 staining was seen in all 66 cases of adenocarcinomas, regardless of Gleason score.
Plasmatocyte differentiation starts prematurely in early third-instar larvae, and by the late third-instar stage, the majority of cortical prohemocytes, including the hemocytes in the inner layers of the gland, were positive for the plasmatocyte marker.
b Showing massive layer of mixed brunners gland filling almost of the submucosa.
Additionally, the expression of androgen receptor (Ar), which is enriched in the basal layer of the sebaceous gland and in outer root sheath keratinocytes of the hair follicle [22], was dramatically suppressed in skin of SKO mice (Table 3).
Aldosterone is secreted by zona glomerulosa (ZG) cells located in the subcapsular layer of the adrenal gland cortex.
The ER-positive breast tumors are referred to as luminal tumors, indicating that these tumors supposedly originate in the luminal cell layer of the breast gland.
Immunohistochemical and mRNA expression profiling studies of large breast cancer cohorts have reproducibly identified a subset (about 15%) of tumors expressing markers of the basal layer of the mammary gland [ 22].
Immunohistochemical and mRNA expression profiling studies of large breast cancer cohorts have reproducibly identified a subset of tumors (~15%) that express markers characteristic of the basal layer of the mammary gland.
The most EMTed breast cancers belong to the Claudin-Low subtype and are likely derived from the highly plastic cells of the basal layer of the mammary gland; the less plastic luminal cells, in contrast, are thought to give rise to the Basal subtype (Taddei et al, 2008; Lim et al, 2009; Molyneux et al, 2010) (Fig 2B).
