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The juxtamembrane domain, which forms an important layer of constraint, limiting promiscuous enzymatic activity of RTKs, is found frequently mutated in tumor cells [ 25- 32].
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This implicates that being expressed in brain represents an additional layer of constraints on transcriptome evolution (Khaitovich, Enard, et al. 2006).
Specifically, the proposed framework integrates multiple layers of constraints to favor certain routes and to study the effects of the proposed recommendations.
In this work we go one step forward in that direction and use a framework based on potential energy landscapes to integrate diverse layers of constraints to favor certain routes and to study the effects of the level of adoption of the proposed recommendations.
Table 5 reports the layers, number of constraints, and the number of references specified in DCL 2.0.
Additionally, the proposed configuration presents superior performance in a broadband frequency range when compared to a viscoelastic damping constraint layer of equivalent mass.
The RNN is comprised of two layers, namely, variable layer and constraint layer, which correspond to the number of design variables in the problem.
We analyze the lifetime of clustered sensor networks with decentralized binary detection under a physical layer quality-of-service (QoS) constraint, given by the maximum tolerable probability of decision error at the access point (AP).
Rarely the product of free and rational choice, confessions "arise in situations of constraint, whether physical or psychological," he says, "motivated by inextricable layers of shame, guilt, disgrace, contempt, self-loathing, propitiation and expiation".
The two sampling zones shared about 30% of OTUs (Table S1), indicating the ability of some picoeukaryotes to colonize the whole mixolimnic layer of the lake, regardless of oxygen constraints.
Inverted resistivity measurements were used to generate a surrogate for a spatial map of clay layer thickness, with constraint provided by coring the riverbed at selected high and low resistivity locations to independently determine the thickness of the clay.
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