A remapped late template would have spatial-temporal correlations values comparable with the shuffled ones, ∼0.2.
We found that the population of early template spatial-temporal correlations was not different from the population of late template ones in both control and mutant mice (revised Figure 5 figure supplement 1).
Please also note the majority of significant correlations (preplay and replay) do not reach an absolute value of 1; this means, for example, that an early template and an edited late template could both have significant spatial-temporal correlations of 0.7 value with the same spiking event from the preceding sleep.
In order to answer the latter question, we constructed spatial templates from the activity of place cells in the first four laps of run (early templates) and the last four laps (late templates), and correlated them with the temporal sequences recorded during the previous sleep (early and late preplay).
In order to address this question, we constructed spatial templates from the activity of place cells in the first four laps of run (early templates) and the last four laps (late templates) and correlated them with the temporal sequences recorded during the previous sleep (i.e., early and late preplay).
Moreover, inspired by our cartoon model of temporal-spatial sequences (revised Figure 7), they are asking whether the early and late spatial templates display different spatial-temporal correlation values with the temporal sequences during the preceding sleep.
In this system, isolated late G1 phase template nuclei initiate DNA replication when incubated in cytosolic extracts from proliferating cells [32], [33].
To further investigate the functional roles of hTFIIEα AC-D, we first checked the effects of the hTFIIEα mutants on basal transcription using the adenovirus major late pML(C2AT Δ-50 template.
The latest figure sets the template for this rise.
The user has therefore the possibility to interactively trigger the computation of a new comparative model for the protein of interest based on the latest up-to-date template information.
