These are characters in "With Nothing but a Dream," the latest Origins Project from City Lights Youth Theater.
It unfolds in "Letters of Approval," the latest Origins Project, a collaboration between City Lights Youth Theater and the Lower East Side Tenement Museum.
Aberrant entry into S phase may occur without coordination with supportive metabolic programs, such as nucleotide biosynthesis pathways, and lead to chromosomal breaks, primarily at fragile sites, the latest origin-poor region of the genome to be replicated.
The story, though of late origin, is regarded as plausible by modern historians.
The tethering of Gcn5p to a late origin (ARS1412) causes it to fire earlier [4].
For example, in S.cerevisiae the tethering of Gcn5p to the late origin ARS1412 causes it to fire earlier [4].
Moreover, recruitment of a histone acetyltransferase (HAT) to a single late origin advances Cdc45 binding in yeast and time of firing in both human and yeast [4], [27].
Intriguingly, NUMTs 2 and 28 that we showed display late origin activity are located at orphan peaks whereas NUMT20 that does not, is located elsewhere.
Indeed, the short NUMT28 is at the centre of a 15 kbp region identified as origin by heavy-light microarray [42], that is also recognized as a CDR-1 late origin.
One possibility is that late origin firing results from the topological freedom enjoyed by unrestrained ends.
However, it is unclear why late origin patterns are highly represented at convergent IGR.
