Later follow-up imaging studies should be aimed at detecting local tumour progression, development of new hepatic lesions, or emergence of extrahepatic disease.
Later follow-up imaging studies should be aimed at detecting the recurrence of the treated lesion (i.e. local tumour progression), the development of new hepatic lesions, or the emergence of extrahepatic disease.
Later on ex vivo and animal studies should be considered to demonstrate a photodynamic killing efficacy of ≥3 log10 steps (≥99.9% reduction of viable microorganisms).
Case series studies should be replaced by prospective development studies for early technical modifications and by prospective research databases for later pre-trial evaluation.
Foreign language studies should be enhanced.
In either case, incorporation of 4βHC in phase I studies should be relatively straightforward, and significant changes detected in these studies could be used to trigger a more definitive MDZ interaction study later in clinical development.
Third, we did not adjust for multiple testing, emphasizing that results obtained from a post-hoc subgroup study such as in this study, should be interpreted with caution and optimally confirmed in later studies designed specifically for that purpose.
