With regards to a causal locus, the Lasso, NEG, forward stepwise regression and MCP often select only one of a group of highly correlated variables, and if the wrong one is selected, the true causal locus has little chance of entering the model at a later step, as is evident by flat sensitivity versus 1-specificity curves (data not shown).
The goal of the following section is to define an initial class label vector l, which serves in a later step as an input in the GHMRF-based refinement process.
We also think that the origin of the genetic code is a considerably later step (as advocated by one of the authors): an interim (albeit dirty) RNA world must have prevailed, simply as a consequence of the opportunistic nature of evolution by natural selection.
Cdk1 phosphorylation also influences later steps in HR, as well as expression levels of HR proteins.
Since their discovery in the early 1980s, the Hox genes have been found to play crucial roles from the first steps of development, such as establishing anterior and posterior ends in the zygote, to much later steps, such as the differentiation of nerve cells.
Genes encoding proteins required for the early steps of anthocyanin up to the flavonoid myricetin are also found expressed in the leaf transcriptome, while the genes participating in later steps such as DFR and LDOX are restricted to the flower.
Tyrosinase (EC 1.14.18.1) promotes the first two rate-limiting steps of melanin synthesis from tyrosine to DOPA and DOPAquinone as well as two later steps.
In particular, genistein has proven to be a valuable tool for the inhibition of cancer metastasis, exerting effects on both the initial steps of primary tumor growth as well as the later steps of the metastatic cascade.
The secondary priorities were seen as later steps for investigation.
These mutations may potentially represent genes that play a role in the later steps of metastasis, such as colonization.
