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In an alternative model [41] [5], it was argued that KAP-α-mediated transport was the ancestral mode, and that later KAP-α-independent pathways are a later simplification.
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Later simplifications merge the ten dinucleotides representing unstable base pairs into a single "mismatch" state, resulting in models with seven states (Tillier and Collins 1998; Higgs 2000).
We ignore resources involved in this reaction to simplify the models constructed later (this simplification does not affect the general conclusions of the current study; see Authors' response to Reviewer's report 3 for more explanation on this assumption).
Simulation results that we will present later show that this simplification does not affect the validity of the conclusion of our analysis.. lR M = 1.25TRA and R m = 0.75TRA.. mThe code of this simulator is available at http://fourier.networks.imdea.org/people/~marco_gramaglia/sims/ETSI-SLAAC/.
Thus for simplification, we used the later parameters setting.
Later, they can be subject to step-wise simplification by removal of interactions or simplification of reaction kinetics.
Later in Section 4, we introduce some simplification and develop the proposed centralized and distributed user association techniques.
For notation simplification, we omit the frequency bin indices later.
Nearly seventy years later, we are in the midst of a re-simplification of electronically produced music, a revival of the days when producers were scientists, creating and programming the means to create music before the actual music itself.
Earlier concepts of distinct disease phases, from an early 'pro-inflammatory' to a later 'fibrotic' phase, now appear to be an over-simplification.
Simplification of cell shape seems to be a later event which could fit with a secondary activation of actin/cell architecture pathways.
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