Of these mothers, 4685 did not have a fetal crown to rump length measurement, mainly because of a later enrolment in the study.
Hence, the review authors divided these trials into three categories based on different entry criteria: entry in the first three days of life according to oxygenation criteria, routine use in intubated preterm babies and later enrolment based on an increased risk of CLD.
However, trials of early treatment of infants based on oxygenation criteria or of later enrolment based on the risk of CLD did not demonstrate significant benefit of iNO for the primary end point of death or CLD at 36 weeks, when analyzed according to standard aggregate data meta-analytic techniques.
Personal, 24-h MF exposures were monitored prospectively, with the first measurement taken shortly after enrolment and later measurements taken at the beginning of the second and third year after enrolment.
All patients were tested with the ICT-TB on the day of enrolment or not later than 3 days after enrolment.
After enrolment, 32 patients were later excluded; 29 patients because they were concurrently on antibiotics; two patients secondary to steroid use and one because of tendon involvement.
We investigated the patterns of re-enrolments in more detail and found that in 31.1% (1,561) of the cases, re-enrolment was associated with a change to a new doctor, and in 30.8% (1,547) the patient was missing at least two documentation intervals before the time of re-enrolment, indicating removal from the DMP and later re-enrolment.
Table 3 illustrates the negative influence of lacking social and economic support on the timing of ANC initiation: In particular not possessing money in cash when attending the ANC clinic (p = 0.064) and not receiving support from the husband/partner (p = 0.035) were independently associated with a later ANC enrolment in the multivariate analysis for all women.
Self-reported, prolonged complete abstinence from smoking (a) between six weeks after enrolment in the scheme and prior to childbirth; and (b) between childbirth and six months later.
Moreover, we were not able to repeat T-SPOT.TB at later time points before culture-confirmed active tuberculosis was diagnosed, because cells samples were collected only once a year after enrolment in the Swiss HIV Cohort Study according to the protocol.
