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The state of Rio de Janeiro was the site of introduction and later dissemination of these serotypes after epidemics in the years 1986, 1990, and 2002 [ 4].
Since massive proliferation is seen in the later dissemination state when the fungus colonizes other organs, it must be able to obtain enough nutrition for growth from the organs [ 8].
2. Set up an Expert Panel of clinicians and consumers to assist with access to, and interpretation of the clinical and health economics literature and for later dissemination of findings.
Efforts were made in later dissemination rounds to increase responses from groups that proved to be more challenging to access and were initially under-represented (i.e. general practitioners, geriatricians and old age psychiatrists, people with dementia, people with no direct experience of dementia, and people from black and minority ethnic groups).
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In nonhuman primates, rabbits and guinea pigs a heterogeneity of lesions is observed comprising of initial hypoxic, necrotic primary granulomas and then secondary inflammatory lesions which originate at a later stage after dissemination [5], [6], [7], [8].
Two of the 3 deaths that were thought to be related to candidal infection were a result of dissemination of disease, indicating that cases with "apparent isolated candiduria" may later disseminate or may have undetected foci of infection at non-renal distant sites.
This last result suggests that at least some of the early CBC may be part of a generalised metastatic process and that late CBC comprises two types – independent CBC associated with age and CBC reflecting later metastatic dissemination.
The later stages of dissemination, implementation, and posterior evaluation of their impact complete the cycle for dynamic change in clinical practice.
Detachment of the ECM during early carcinoma formation or in the later stages of dissemination and metastasis robustly induces autophagy to promote cell survival.
Some studies have shown that a lack of appropriate ECM contact also robustly induces autophagy to promote cell survival, either during early formation of carcinoma or in the later stages of dissemination and metastasis [ 61, 62].
Three weeks later, the peritoneal dissemination of the HSC-44PE/LUC cells was visualized using Living Image 3.2 (Caliper Life Science, Hopkinton, Mass, NA, New England); the animals were then sacrificed by cervical dislocation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com