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This paper described a specific time schedule of atrial contraction (early atrial activation of midseptal annulus and roof and later activation of the anterior and lateral annulus were suggested).
Susceptibility could either result from the host lacking the required defence genes i.e. uncertainty in activating the correct response or it could be due to a later activation of the defence genes compared to a resistant host [ 36- 39].
In addition, in the AMB condition the conscious awareness of asynchrony might be associated to a later activation of the primary auditory cortex.
Early activation of the PDI gene and later activation of thioredoxin gene suggest that these enzymes cooperate to combat the oxidative stress caused by chilling.
The modulation of the major antioxidant enzymes suggests a response mounted towards maintaining the redox status, since both GPX and CAT (with a later activation of SOD) are upregulated.
Our results also show that transient early activation of the Wnt/β-catenin pathway has no effect on cardiogenesis, while later activation of the pathway antagonizes cardiac differentiation.
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Instead, the C′→O′ transition, representing later activation transitions of the channel protein, yields the transient increase in Q 10 when the obligatory voltage-sensor control is alleviated.
In a rat model of carrageenin-induced pleurisy, early activation of NFκB in leukocytes induces the transcription of pro-inflammatory genes, while later activation results in the expression of anti-inflammatory genes.
In fact, the first model (repressed but poised for later activation) implies that most of the cells harbour coexisting repressive and activating marks and that both PcG and trxG have to be maintained at the given locus through cell divisions to keep the repressed-but-poised status until further changes in the balance of their activity.
On the other hand, higher levels of sCTLA-4 could contend the binding of the membrane form of CTLA-4 with CD80/CD86, in later activation phase, causing a reduction of inhibitory signalling.
Expression of the later activation marker CD25 was also decreased in Gli2ΔN2 transgenic cultures on both CD4 and CD8 T cells, from 47% and 72% in WT CD4 and CD8 T populations, respectively, to 17%and9%9% in their Gli2ΔN2 transgenic counterparts.
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