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The two-step requirement of hsf-1 suggests that there might be an initiation phase required by hsf-1 during development that is later acted upon during adulthood.
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It could be inferred that that early glucocorticoid exposure results in Agtr1b changes, whereas later exposure acts upon blood pressure regulation through an independent, sexually dimorphic mechanism.
This suggests a two-stage process: first the functioning of the sense faculty results in "mere seeing" of the object (non-conceptualized awareness) and, later this mere seeing is acted upon by the intellect or mind and results in a conceptual identification of the object.
Erroneous advice The case officer in question often gave no reply at all to my correspondence and on one occasion she gave me erroneous advice that she later had to retract – luckily before I had acted upon it.
"If those lessons are not acted upon, we are destined sooner or later to add again to the roll of names".
Two and a half years later, there were still 167 keys marked as removed that have not been acted upon.
So they acted upon it.
They weren't acted upon.
This is automatically acted upon.
And acted upon.
It is continually acted upon by nature.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com