In addition, AMPs have potential to be used in treating persister cells, which are latent phenotypic variants highly tolerant to antibiotics [ 129, 130].
In contrast, both the latent form of PAI-1 and the stable variant of PAI-1 inactivated by a specific neutralizing monoclonal antibody, or the stable variant of PAI-1 in a complex with recombinant urokinase did not inhibit apoptosis.
Bearing solely one of those variants, patients are asymptomatic or only have a latent form of LQTS, respectively (Crotti et al, 2005).
We previously found that although the stability and inhibitory activity of the human α1AT variant Mmalton (Phe52-deleted) are comparable to those of wild-type α1AT, the Mmalton variant spontaneously undergoes a conformational change to a more stable, inactive, latent form under physiological conditions.
These studies have identified three classes with specific biological properties: latent and PM-inducing variants of 335 338 nt (31,32), and PC-inducing variants of 348 351 nt with a 12 14-nt 12 14-ntn that containsertionathatenicontainserminanthe34]–[36].
These mutations evolve from 215 resistant mutations after primary infection with resistant strains and therefore are supposed to indicate the latent presence of resistant variants.
In GWAS, researchers assume that the genetic variant explains variance in the latent trait, and that the effect of the variant on individual items or symptoms is mediated by the latent trait (Figure 1a).
The genetic variant explained 1% of the variance in one of the latent factors (note that this genetic variant is related to the test items but only via the latent factor).
We derive the connection between the cumulative risk of the SNP variants to the latent genetic risk model and heritability of the disease.
To overcome this restraint we have examined by deep sequencing (Solexa-Illumina) and computational approaches the vd-sRNAs accumulating in GF-305 peach seedlings infected by two molecular variants of Peach latent mosaic viroid (PLMVd) inciting peach calico (albinism) and peach mosaic.
