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The new study takes an unusually precise approach to dislodging the latent pool.
The latent pool shows minimal or absent decay (8), which is not fully understood.
In addition, the 75% reduction of the latent pool does not impact a patient's health, says Robert Siliciano of the Johns Hopkins University in Baltimore, Maryland.
FoLurkingrtin Robbins on Twitter.
Furthermore, this latent pool is populated predominantly by R5 viruses [41].
To achieve the burst of lymphocyte proliferation which initially establishes the latent pool, gammaherpesviruses have to escape the host immune control [47].
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Fauci and others earlier had similar success with interleukin-2, but when treatment stopped, HIV quickly surfaced and refilled latent pools within weeks.
Accordingly, it was previously reported that saponins unmask a latent intracellular pool of (Na+,K+ -ATPase leading to an increase in the renal tubular ATPase activity [ 35, 36].
This chronic depletion of the latent complex pools presumably restricts TGF-β activity, and results in a subtly altered proliferative phenotype in liver and lung.
There was no correlation between active and total TGF- β1 levels, implying that the activation was not dependent of the total pool latent TGF- β1 present in the tumour microenvironment.
After 4 months, the amount of infectious HIV in each patient's pool of latent cells declined an average of 75% in three of the four patients studied, the investigators report 13 August in The Lancet.
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