Sentence examples for latent molecules from inspiring English sources

TGF-βs are secreted as latent molecules and require activation prior to binding their signaling receptor and the generation of active cytokine is one of the major regulators of the TGF-β signaling pathway.

They activate latent molecules released from the matrix.

Many of these proteases also modulate other cellular functions, either directly by interacting with receptors at the cell surface or indirectly by activation of latent molecules in the extracellular milieu.

Curiously, while TGF-β1 is considered an anti-inflammatory cytokine, it induces leukocyte recruitment.[8], [9] TGF-β1 activity is controlled predominantly through activation of the latent molecule.

However, TGF-β is secreted as a latent molecule requiring activation by tissue plasminogen activator and tissue plasminogen activator has been demonstrated to be expressed on CD103+ DC from the mesenteric lymph nodes raising the possibility that PP-DC may also result in the generation of higher amounts of active TGF-β [35].

Thus as soon as the latent molecule is formed a specific interaction with an active molecule of antithrombin effectively blocks the exposed β-interface, pending the catabolic removal of the senescent molecule.

The sequence of the peptide section (AVVIA) of the reactive loop of active antithrombin that occupies the vacated site in the C-sheet in the latent molecule bears no apparent relationship to that of the displaced strand (VTFKA).

The specific and early effect of adrenomedullin on RA-FLS adhesion to ECM proteins suggested activation of latent adhesion molecules.

The CB complexes are mainly formed by proteins and latent mRNA molecules, which can distort the levels of gene expression in transcriptional analyses of neoblasts samples.

The instability of fibrillin-1 may cause an uncontrolled release of TGF-β, which is normally sequestered in the ECM as a latent inactive molecule, with consequent activation of fibroblasts and excessive collagen synthesis, ultimately leading to tissue fibrosis [ 21].

The intermolecular linkage between the latent and active molecules involves a number of contacts outside and beyond those formed by the replacement strand.