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It was a claim that McCarthy never substantiated but by his fall from grace in 1954 his Permanent House Committee on Investigations had destroyed countless careers and given a veneer of respectability to latent establishment anti-Semitism.
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This provirus being inert to the host immune system is ideal for latent reservoir establishment in vivo.
To further investigate the establishment of latent infection due to GFP-EBV, the latent protein expression profile of the critical latent antigens in these GFP-EBV transformed LCLs were analysed.
Distinct viral promoters are turned on during the establishment of latent EBV infection in B cells and epithelial cells, and differential latent EBV genes are transcribed (type III latency program in B cells and type II latency program in epithelial cells).
Establishment of latent infection within specific tissues in the host is a common biological feature of the herpesviruses.
Persistence is achieved through the establishment of latent infection in conventional memory B lymphocytes.
Although AAV is known to replicate by a hairpin priming mechanism, a rolling circle mechanism has been proposed during the establishment of latent infections [60], [61].
The Wistar rat is a valuable model for better understanding host-pathogen interactions that result in control of Mtb infection and potentially establishment of latent TB.
Primary HSV-1 infection is often followed by the establishment of latent infection in the peripheral nervous system (PNS), usually in the trigeminal ganglia.
It has been reported that even in the Cynomologus macaque model, which is the representative animal model depicting human TB, the amount of gross disease seen at 60 days post-infection could not predict the establishment of latent disease [22].
Thus the incubation time used in our study may contribute to account for the high levels of IFNγ responses to CFP-10 observed in HHCs and the establishment of latent tuberculosis infection amongst HHCs.
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