Sentence examples for late stage discovery from inspiring English sources

This lack of basic knowledge of NPC might be a fundamental cause for late stage discovery of the disease by GPs.

Given the poor prognosis due to late-stage discovery of the disease, and the fact that CCA commonly manifests at or after the age of 40, with males being more commonly infected than females, not only is the patient directly affected, but the family for which he or she is responsible is also liable to socio-economic hardship [ 29].

At a late stage in discovery, combinations are typically tried based on the convenience of sourcing and what is topical at the moment.

The scores in Table  3 furthermore indicate similar diagnostic accuracy independent of the stage of AD patients: AUC values were comparably high for late stage (mean MMSE discovery set = 5.5 ± 4.2) and mild/moderate stage (mean MMSE verification set = 14 ± 7.1) AD patients as evident in e.g. model 5 with AUC values of 0.952 (discovery phase) and 0.980 (verification phase).

One of the systems pharmacology goals is to use modeling to help decrease the high rate of attrition happening in the late stages of drug discovery pipelines.

Regardless of the production method, ultimately, compounds must be positively identified and they must be of a high quality with sufficient purity and quantity to identify hits against disease targets, but to support late-stage drug discovery studies including toxicology and pharmacokinetics.

In addition, examples are described that show that structure-based drug design can support the drug discovery process at a very late stage.

This review highlights our current knowledge on the genetic architecture of early and late stage AMD and explores its potential for the discovery of novel, target-guided treatment options.

Because the compound optimization and pharmacological research are in very late stage, we focus on the early stage of antiviral discovery in this work.

Patient delay in presenting for medical help after symptom discovery is likely to contribute to late stage at diagnosis.

Different computational approaches for ligand discovery have been developed helping to reduce late stage attrition and to limit the number of expensive and time consuming experiments required to synthesize the active novel hits with optimized pharmacodynamic and pharmacokinetic properties [47].