The late response usually is associated with an increased responsiveness of the airways to various stimuli, including inhaled histamines and methacholine.
In habituation paradigms, early and late responses can behave differently as a result of regulation by different mechanisms; according to the dual-process theory, increasing responsiveness (sensitization) competes with decreasing responsiveness (habituation) to determine final behavioural outcomes.
In addition, De Boer et al. [ 46] showed that the increased formation of the highly reactive procontractile and proinflammatory oxidant peroxynitrite plays an important role in airway hyperresponsiveness after the late airway responsiveness.
The public's appreciation of this fairly late-onset responsiveness was obvious in the final, relatively idyllic days of the pre-referendum era, with the palace's 90th birthday celebrations designed to exhibit the monarch's bond with her people.
This model shares many characteristics of the disease in humans, including the development of early airway responses (EAR) and late airway responses (LAR) and postantigen-induced airway hyper-responsiveness (AHR) after inhalation challenge with Ascaris suum antigen (Abraham 2000).
This placebo-controlled study assessed the effects of the once-daily inhaled corticosteroid (ICS) fluticasone furoate (FF) and long-acting beta2-agonist (LABA) vilanterol (VI) on early and late asthmatic responses (EAR/LAR) and airway hyper-responsiveness (AHR).
To report clinical conditions and neuropsychological functioning of patients with late recovery of responsiveness at least 5 years after injury.
To investigate the extent to which the ROSA could measure relevant changes due to a treatment in patients with early, middle, and late AD, the responsiveness of the ROSA to change was assessed comparing baseline ROSA data with the ROSA total scores after 12-week treatment with memantine.
20 There is ample evidence that the presence of comorbid cognitive deficits is associated with reduced treatment responsiveness in late-life depression.
The purpose of the sleep questions was to identify symptoms suggestive of circadian sleep phase disorders, such as evening drowsiness or prolonged sleep latency, early awakening or tending to awaken late, which might suggest particular responsiveness to bright light treatment.
