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For the more complicated DNA viruses, such as adenoviruses and herpesviruses, some regions of the genome synthesize "early" mRNAs, which are translated into polymerases that initiate the transcription of "late" regions of the DNA into mRNAs, which are then translated into structural proteins.
The genome organization into early, intermediate and late regions is similar to HAdV-A12.
Additionally, RferPV1 contained a second noncoding region between the early and late regions.
There are 7,914 genes expressed in Early regions compared to 7,557 genes in Late regions.
Replication timing of megasatellites presented a bias for late regions (Fisher exact test p value = 0.03146), but when subtelomeric megasatellites were discarded, the remainder did not exhibit any bias regarding replication timing (Fig. 3e).
Methylation of the human papillomavirus (HPV) late regions is an indicator of the length of time that the genome spends in a given host tissue, and appears to be a proxy for viral persistence, cell immortalization and progression.
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In the dual fiber-expressing vector Ad5/R7-ZZwt/E1 WTFib, the early region E1 located at the left-end hand of the viral genome was deleted and replaced by the gene coding for WT fiber, whereas the late region L5 encoded the knob-deleted, shaft-truncated ZZwt-liganded fiber [18].
The genes for Shiga toxin (stx2AB) are located on a prophage in the late region between genes Q and S and are transcribed with the late region genes from promoter P R' (Tyler et al. (2004) ).
The late region encodes three capsid proteins, VP1, VP2, and VP3, and a small regulatory protein called agnoprotein.
They all have two polyadenylation signals that divide the genome into an early and a late region.
HPVs have a genome that is divided into three regions: an early region (E), a late region (L), and a non-coding long control region (LCR).
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