Sentence examples for late onset development from inspiring English sources

However, we have recently discovered that RIα heterozygosity alone produces phenotypes that include sperm abnormalities and subsequent infertility [23] as well as late onset development of soft tissue sarcomas, hemangiosarcomas, chondrosarcomas and hepatocellular carcinomas [24].

Little is known about the progression of neural injury over time and how this injury progression contributes to late onset seizure development.

With the exception of a dose-dependent decrease in water intake that was attributed to unpalatability, the NTP authors characterized the exposure to Cr VI) as well tolerated (NTP, 2008b); thus gastrointestinal problems such as bleeding or malnourishment were not observed and suggest late onset tumor development.

However, the late onset of tumour development suggests that additional events must occur for the manifestation of the effects of transgenic expression of LPA1.

The late onset and stochastic tumour development suggest that expression of ATX or the EDG-family LPA receptors cooperates with other events such as secondary mutations to generate the full tumourigenic phenotype.

Progressive deterioration of muscle strength of knock-in mice mirrors the development of late onset muscle weakness reported in patients [1], [3], [45] and transgenic mice expressing R155H VCP [31].

Moreover, a recent study showed a strong association between certain IDE polymorphisms that are able to modify brain IDE transcription levels and the development of late onset AD [50], [51].

It is possible that the lack of effect of tra F with the ppk23-GAL4 driser is due to the late onset of ppk23 transcription during development.

It is hypothesized that heterozygous PINK1 mutations are a risk factor for the development of late onset PD (Khan et al. 2002).

The most common form of the disease (incidence 1/500-1000) is autosomal dominant PKD (ADPKD) that is typically a late onset disease characterized by progressive cyst development and often resulting in end-stage renal disease (ESRD) [ 3].

In this study, the authors tested the hypothesis that SCA13 mutations associated with early or late onset have differential effects on neuronal development that could underlie the age at which disease emerges.