Treatment interruption was defined as any observation time between therapy initiation and latest observed event with documented treatment discontinuation.
Hazen-Martin et al. [ 32] reported in cultures of human proximal cells exposed to Cd, alterations in TER and in the structure of apical cell membrane junctions, latest observed by freeze-fracture microscopy.
The late Richard Hoggart observed the widely held belief that a "bloodless revolution" had taken place in Britain following the second world war, based on the founding of the welfare state and the slow re-emergence of a consumer economy.
There were late complications observed: plate intolerance due to interference at the insertion of the hamstrings tendons were treated by removal.
With this conceptual setting, it becomes possible to simulate the sharp front of concentrations at early times and the flat tail of low concentrations at late times observed on the experimental breakthrough curves.
The acute and late toxicities observed with CIRT are shown in Table 2.
The most frequent late toxicity observed was G1 urinary frequency in 17 out of 46 (37%) cases.
This death pathway might account for the late apoptosis observed after IR or adriamycin treatment of breast cancer cells.
The high mortality in relation to late diagnoses observed in this national cohort is in keeping with other surveillance data [ 19, 20].
Together, the accelerated inactivation, reduced channel availability, and decreased late current observed after FGF14 knockdown bias NaV channels to the inactivated state.
