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CSF opening pressure at baseline was highly associated with development of blindness, but there was no association with papilloedema, which probably reflects the fact that papilloedema is a late indicator of raised intracranial pressure.
Although sCr is widely used for assessing renal function, it has inherent limitations as a late indicator of renal dysfunction and an inaccurate detector of mild renal impairment [ 22].
We examined nuclear morphology in experimental and control knockdown cell lines to look for relatively early indicators of apoptosis in order to complement studies described above in which apoptosis was measured using a relatively late indicator (e.g., cleaved lamin A).
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In current clinical practice, AKI is diagnosed by measuring Cre and/or blood urea nitrogen levels, but these markers are insensitive and late indicators of AKI [2].
Traditional biomarkers like creatinine are late indicators of AKI, delaying diagnosis by days [ 5].
Similarly, normalized morphology and organ function are late indicators of response to treatment, preceded by restorative cellular and molecular responses.
Calcium responses, and also late indicators of T-cell activation such as IL-2 release, were also diminished in TCR-activated Jurkat cells expressing human CD6, compared with CD6-deficient cells or cells expressing a cytoplasmic deletion mutant of human CD6.
The climb down was the latest indicator of the shifting balance of power in Asia.
The introduction of video sharing on Instagram feels like the latest indicator of that disconnect.
The quarterly Tankan report is the latest indicator in a grim flood of statistics documenting Japan's woes.
Meanwhile, back in America, the jobs report last Friday is the latest indicator that we may face a very deep and perhaps very long recession.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com