Further elucidation and modeling of medical translational research is highlighted by the National Cancer Institute (NCI) in their translational continuum schematic, which outlines five phases of translational research: basic science discovery, early translation, late translation, dissemination, and adoption [8].
Pancreatic ductal adenocarcinoma (PDAC) is one of the five most common causes of cancer death, owing to its late diagnosis, high dissemination at early stages, and poor responsiveness to both radio- and chemotherapy [ 1].
We used nonreplicating vectors so that we did not observe virus dissemination at late time points (Wang et al, 2003).
The current findings are therapeutically relevant as early metastatic dissemination and late relapse represents a significant threat to long-term survival of patients with ER+ MC.
It is often diagnosed at a late stage with peritoneal dissemination and massive ascites, and despite combined treatments of aggressive cytoreductive surgery with platinum- and taxane-based chemotherapy the 5-year survival rate remains only 30% [ 1].
Reasons may include: a lack of evidence to base information on and the need to update resources according to the latest evidence; challenges with dissemination (e.g. translating evidence into readily accessible and understandable resources); and barriers to implementation (e.g. enlisting the support of organizations and clinicians).
(H6) For dissemination of the latest antivirus software, a q fraction of infected internal computers get recovered at time instant kT, where (0< q< 1), and q is a constant. .
For dissemination of the latest antivirus software, a q fraction of infected internal computers get recovered at time instant kT, where (0< q< 1), and q is a constant.
The logistical challenges of placing skilled instructors at these distant sites limit the global dissemination of the latest best practices in patient care, and strategies are needed to expand the impact of high-quality instructors, advances in medical knowledge, and new technologies.
Inadvertently, this limits the ability of universities to increase the involvement of medical school faculty in the provision of high-quality patient care, dissemination of the latest technology, and translational research with immediate patient benefits.
