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"lasting significance" is a correct and usable phrase in written English.
It can be used to describe something that has a deep and enduring impact or importance. Example: The discovery of penicillin has had a lasting significance in the field of medicine, saving countless lives and revolutionizing the way we treat infections.
Exact(60)
Producing something of lasting significance is the hardest challenge.
How many have the depth of understanding necessary to create works of lasting significance?
We as a civilization have few things we can accomplish of lasting significance.
Nevertheless, accomplishments with lasting significance have resulted from some one-term presidencies.
Moreover, some of the Lithuanian artists who opposed Soviet ideological constraints produced theatre and art of lasting significance.
His emphasis on the influence of economic structure on historical development has proved to be of lasting significance.
Or that crash-coaching courses for local youngsters will, in the opinion of youth workers, be without lasting significance.
Hobsbawm said he thought the Persian revolution of 1978/9 was probably comparable with the French revolution in terms of lasting significance.
The colony experienced many hardships, but lasting significance resulted from its founders' emphasis on family migration, equality of creeds, and free market forces in land and labour.
While these events were not of lasting significance, Sallust's experience of the political strife of that year provided a major theme for his writings.
Neither Decadence (with the exception of Huysmans's Against Nature and Mirbeau's The Torture Garden) nor Symbolism generated novels of lasting significance.
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com