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However, our numerical model also suggested that lasting activation of these receptors restore physiological intracellular chloride concentrations and suppress HPDs.
We found that YopM induces long lasting activation of RSK even in the absence of upstream ERK-signalling.
In RPE cells the switch to a persistent mesenchymal state following prolonged wound stimulus is driven by lasting activation of the TGFβ pathway.
These results indicate that, in a critical developmental period, apparently nontoxic exposures to CPF produce lasting activation of 5HT systems in association with 5HT-associated behavioral anomalies.
To analyze the effect of a long lasting activation of RhoA signaling, constitutively active RhoA was overexpressed in glEND.2 cells.
In contrast, Lef-β-catenin-GR protein can be activated very efficiently by dexamethasone at will, leading to strong and lasting activation of Siamois and Xnr3 (Fig. 8C).
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Spiral computed tomography (CT) images were taken immediately before the RME and 3 months after the last activation of the appliance using the Xvision EX spiral machine (Toshiba Medical Systems, Otawara-Shi, Japan).
In other trials, however, an immediate or delayed long-lasting activation of dural nociceptors was observed [1] and the mechanism of this activation is less clear.
This suggests that the ageing process is associated with and/or a consequence of a long-lasting activation of the major stress responsive systems.
In a model of endotoxemia, it was observed a long-lasting activation of microglia, but not astrocytes, and this was associated with decrease in expression of plasticity related genes and brain neurogenesis [94].
In conclusion, the modified EGF had significantly higher binding affinity for apatite and titanium than soluble EGF, and the bound EGF significantly enhanced cell growth by long-lasting activation of intracellular signal transduction.
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