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However, our numerical model also suggested that lasting activation of these receptors restore physiological intracellular chloride concentrations and suppress HPDs.
We found that YopM induces long lasting activation of RSK even in the absence of upstream ERK-signalling.
In RPE cells the switch to a persistent mesenchymal state following prolonged wound stimulus is driven by lasting activation of the TGFβ pathway.
These results indicate that, in a critical developmental period, apparently nontoxic exposures to CPF produce lasting activation of 5HT systems in association with 5HT-associated behavioral anomalies.
To analyze the effect of a long lasting activation of RhoA signaling, constitutively active RhoA was overexpressed in glEND.2 cells.
In contrast, Lef-β-catenin-GR protein can be activated very efficiently by dexamethasone at will, leading to strong and lasting activation of Siamois and Xnr3 (Fig. 8C).
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Hypertension may be a result of a lasting sympathetic activation [6].
Thus the deactivation of regions involved with cognitive control observed with the cocaine-cues video in the females could reflect a long lasting effect that follows the exposure to conditioned-cues in contrast to the fast and short lasting limbic activation from cues exposure.
Spiral computed tomography (CT) images were taken immediately before the RME and 3 months after the last activation of the appliance using the Xvision EX spiral machine (Toshiba Medical Systems, Otawara-Shi, Japan).
The vertical bars represent the range of times from first to last activation and from first to last repolarization.
The last activation protocol was a card flipping task in which the subject was asked to flip individual cards from one deck to a separate deck of cards.
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