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The last was calculated using codes of the International Statistical Classification of Diseases and Related Health Problems, ninth revision.
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We chose 1997 both because it allowed us to use 2000 census data and because it allowed comparison with the Dartmouth Atlas of Health Care general medical HSAs, which had last been calculated for the 1996 edition [ 13].
Standard PK parameters (area under the concentration time curve [AUC], maximum serum concentration [ Cmax], time to Cmax [ Tmax], apparent terminal elimination half-life [ T½], AUC0-inf and AUC0-last) were calculated by noncompartmental methods using WinNonlin 6.0 (Pharsight Corporation, St . Louis MO).
This last parameter was calculated employing two processing methodologies, finding a good general agreement between them.
Then, the value in the last period was calculated by a simple recursive equation with the proposed stepwise iteration method and the value function was fitted with a linear regression model.
Next, the life event load before the first or since the last admission was calculated.
This last component was calculated as the shortest distance from each experimental data point to the microtubule track.
Age at diagnosis or last visit was calculated for KS cases or KS-free participants, respectively.
AUC from baseline to the last assessment was calculated using the trapezoidal rule.
A muscle time span (in seconds) between the activation of the first muscle to the muscle to be last activated was calculated.
It is worth saying that this last percentage was calculated on 3 children only (1 out of 3).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com