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At 90 days following the last TBI or sham procedure the animals were cognitively tested in the Morris Water Maze (MWM), euthanized, and the brains removed for immunohistochemistry.
Intervals from the last TBI differed.
Veterans with combat TBI were seen 122.6±4.4 weeks after the last TBI (range 40 212 weeks).
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Four phases may be distinguished: an acute phase, which lasts 24 hours after TBI; an early subacute phase, which spans from the days 1 to 13; a late subacute phase, from days 14 to 20; and a chronic phase, which starts on day 21.
When cognition was assessed at different times after TBI, only the last day was considered.
Post-concussion syndrome, a set of lasting symptoms experienced after mild TBI, can include physical, cognitive, emotional and behavioral problems such as headaches, dizziness, difficulty concentrating, and depression.
Due to an increasing clinical experience and improved treatment algorithms, overall mortality decreased during the last decades in traumatized children with TBI [ 5].
320,000 likely have a TBI.
TBI could result in lasting deficits due to brain damage.
In clinical practice, decompressive craniectomy in TBI is typically an intervention of last resort.
Early- and delayed-onset transient changes after TBI were defined as those changes lasting more than 24 h but not after 72 h postinjury.
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