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Exact(4)
They limited the review to the largest trials in both groups to 8 homeopathic trials (with at least 98 subjects) and six conventional trials (with at least 146 subjects).
One of the largest trials in our review came to an explicit conclusion that mechanisms to feed back evidence about outcomes to partners was " the most important factor [for sustainability], cited in four of the five IMPACT study sites".
The largest trials in patients with advanced-stage HCC are the SHARP (sorafenib HCC assessment randomised protocol) (Llovet et al, 2008b) and the Asia-Pacific liver (Cheng et al, 2009) phase III studies evaluating sorafenib vs placebo.
One of the largest trials in this regard was conducted by Miranda-Filho and colleagues [ 76], who randomly assigned patients to two groups to receive either intramuscular HTIg (3,000 IU) plus intrathecal HTIg (1,000 IU) or intramuscular HTIg alone.
Similar(56)
The largest trial in humans showed similar levels of weight loss between people put on a two day consecutive fasting diet and a regular calorie-controlled diet.
The Angioplasty and Stent for Renal Artery Lesions trial (ASTRAL) in which our centre participated has been by far the largest trial in atherosclerotic renovascular disease (ARVD), recruiting 806 patients [15].
The largest trial in this group was that of Richardson et al. (52), which evaluated 36 participants.
Even the effect size from the largest trial in the meta-analysis may be biased sometimes, and often there may be no large enough trial.
Of note, in the largest trial in which a high fraction of inspired oxygen has been tested, no influence on postoperative wound and pulmonary infections was observed [ 58].
Such plausible effects could be: the fixed-effect summary, the random-effects summary or the treatment effect estimate of the largest trial in the meta-analysis, respectively.
Larger trials in west Africa will be able to tell us more.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com