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Another interesting observation made by Brisco et al. is the fact that patients experiencing the largest increase in eGFR also have the largest subsequent deterioration.
Another complication is that patients both need to complete and respond to acute treatment in order to be at risk for subsequent relapse or recurrence; large numbers of patients need to be randomised initially to differential treatment in order to have enough patients remit to detect anything but the largest subsequent differences during follow-up.
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The United States has proposed penalties in the form of larger subsequent cuts in greenhouse gases -- essentially payment with interest.
b Results from groups receiving a smaller priming administration and larger subsequent administration than in the biodistribution and dosimetry study (0.5 + 14.5 and 2.5 + 12.5 MBq, respectively).
If the magnitude of the parent event (e.g., mainshock) is large, subsequent earthquakes that occur shortly after the parent event may be included in the same cluster as their parent, as child events, due to the characteristics of Eq. (1), although they occur at very large distances from the parent event (e.g., in Hokkaido for the Kumamoto mainshock).
Therefore, if the trial yields a positive result, a larger subsequent multicentre study may be needed.
The results by demographics provided some valuable information for the sampling plan in the larger subsequent study.
On the other hand, preliminary interviews in at least two studies helped to construct and validate a larger, subsequent quantitative survey (Day 2006; Engvall et al. 2004).
Higher proportions of AML patients (40%and55%5%) achieved complete remissions in a larger subsequent dose de-escalation study where gemtuzumab ozogamicin was combined with standard chemotherapy [62].
Larger subsequent studies should clarify the effect of exenatide on trends in cardiovascular markers, including weight loss and SBP, and explore the potential for lowering overall risk.
Having 10 participants in each arm of this study was considered sufficient to obtain preliminary data to help with estimating power for a larger subsequent study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com