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One of the largest studies performed, which examined ATR, is the national multisite study Biomarkers for the Rapid Identification of Treatment Effectiveness in Major Depression (BRITE-MD), which evaluated neurophysiologic and genomic predictors of response and remission in MDD.
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The present study on TTV prevalence, mode of transmission and age-specific prevalence is the largest study performed in Central and East Europe.
This project is the largest study performed to date which analyzes differences between CLBP and CWP in primary care settings.
In the largest study performed to date, the PADI4 genotype was not a significant risk factor for RA in people of European ancestry, in contrast to Asian populations.
The largest study performed in the UK population with over 19,000 subjects found no evidence for association between the PADI4_94 SNP (rs2240340) and RA.
To our knowledge this is the largest study performed so far that uses the AGE reader in South Asians, Filipinos and Arabs.
The by far largest study performed by Reynolds and Wasserman in 1942 found that only 15 patients out of 10.000 (0.15%) with syphilis had destructive bony changes [ 2].
Most antibodies provide a highly specific staining pattern that is confined to the cytoplasm with complete absence within the nuclear compartment, as also reported in the most recent and largest study performed hitherto [ 6].
The largest study performed (18) is the one carried out on 1,207 consecutive hypertensive patients who were followed for an average of ∼4 years to determine the risk of events such as myocardial infarction, stroke, and sudden cardiac death.
13 21 In the largest study performed to date, we found no evidence for association between the PADI4_94 SNP and RA in a combined sample of over 19 000 UK subjects.
However, in the largest study performed using self-reported questionnaires, it appears that LBP is less common in former elite athletes (29.3% of 937) than in non-athletes (44% of 620) [ 34].
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