This is the largest study investigating the predictive value of TST versus an IGRA and it is one of few from a high burden setting (Table 6).
To our knowledge, this is the largest study investigating the influence of MBL2 polymorphisms on sepsis susceptibility and survival.
This is the largest study investigating the colonoscopy learning curve to date and included all training centres in the UK.
In the Indian context, this is probably the largest study investigating the effect of 31 genetic variants on various intermediate traits predictive of type 2 diabetes.
To our best of our knowledge, this is the largest study investigating influenza virus detection in the gastrointestinal tract of children with influenza-like illness and diarrhea.
The largest study investigating the relationship between optimism and HRQoL in 1529 patients with chronic diseases found that optimism was positively linked with HRQoL [ 23].
To the best of our knowledge, this is the largest study investigating vaginal prolapse in male-to-female transsexuals after SRS.
Indeed, our study comprised over 7000 events of ischaemic stroke, whereas the largest study investigating sex differences previously, the ATRIA study, only had 369 events; none of the other studies exceeded 100 events.
Although the current study is the largest study investigating the association between dietary salt intake and (early) microvascular complications in individuals with type 1 diabetes so far, a limitation that needs to be addressed is the cross-sectional design.
In contrast, adjuvant treatment was found to yield a significant benefit in the QUASAR study [ 12], which is the largest study investigating the role of adjuvant chemotherapy in UICC II cancer.
