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Toxicity was less than was reported in the two largest studies comparing oral and intravenous regimens (Freifeld et al, 1999; Kern et al, 1999), a discrepancy presumably partly attributable to under-reporting of adverse events by patients after discharge.
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The largest study comparing medication with behavioral modification therapy for attention deficit problems, released in 1999, found that drugs were more effective in improving children's ability to focus and keep still.
The exception was when the largest study comparing hydrogel with a basic wound contact dressing was removed [ 34].
This is to our knowledge the largest study comparing the assessment of individual symptoms between patients and health care providers in cancer care across several countries.
Despite the small number of patients, to the best of our knowledge our study is the largest study comparing both techniques, CK-ICC and RT-PCR, in patients with metastatic colorectal cancer.
Ji et al 10 conducted the largest study, comparing 36 918 people in Sweden hospitalised with PMR or GCA with population controls and, as in our study, found no increased risk of cancer in the long term, but an excess of cancer diagnoses within the first year.
There are no large studies comparing both techniques with resected specimen measurements.
30, 31 Therefore, larger studies comparing both techniques should be performed.
Surprisingly, large studies comparing plasma AGE levels between individuals with and without T1DM are scarce.
There are few large studies comparing the relative side effects and efficacy of different opioids in labour.
Two large studies comparing conventional dose adjuvant chemotherapy with high-dose chemotherapy have been reported in abstract form: the American Intergroup study (ASCO 1999) and the Dutch National Study ASCOO 2000).
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CEO of Professional Science Editing for Scientists @ prosciediting.com