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The largest studies assessing the impact of psychiatric comorbidity on outcomes were mostly performed in patients with acute myocardial infarction and reported conflicting results [4 6].
In one of the largest studies assessing 2,000 breast tumors representing all major subtypes with copy number alteration and gene expression analyses, 10 novel subclassifications of breast cancer were proposed [ 15].
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Herein, we report the largest study assessing CXCL1 expression patterns in human bladder cancer (BCa) tissues.
The largest study assessing TST results enrolled <1,000 undocumented immigrants (17 ); the studies that used IGRAs recruited no more than 125 undocumented immigrants (11, 16 ).
To our knowledge this is the largest study, assessing patient knowledge about OAT in a representative sample of primary care patients [ 11].
To our knowledge, this is the largest study assessing the acute impact of CAPs exposure on HRV in young healthy adults.
As far as the authors are aware, this is the largest study assessing the likelihood of breast cancer patients receiving the treatment decided at MDT meetings.
The THALASSA study is the largest study assessing iron chelation in patients with NTDT, thus allowing for the analyses of the individual subgroups within the NTDT population to be made.
The main advantage is our large sample size, to the best of our knowledge this is the largest study assessing the relationship between reproductive risk factors and serum sex hormone levels in naturally menopausal women and the first one evaluating the relationship between sex hormones and an index that can be used as a proxy of ovarian exposure.
Large studies assessing clinical validity and robust decision models regarding patient outcomes are needed to influence payer coverage decisions regarding SCS [91].
Larger studies assessing the clinical predictors and confirming the beneficial effects of mesalazine are now required.
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