The largest study, analyzing the history of 473 Dutch DMD patients diagnosed from 1961 to 1982, provides limited information, since neither muscle biopsy nor genetic analysis was available for most cases, data was collected by a questionnaire sent to physicians, and clinical practices were not described [8].
To our knowledge, this is the largest study analyzing prenatal origin of childhood leukemias presented so far.
10, 11 Validation of this platform will require larger studies analyzing profiles of these factors for individual patients and correlating results with those of cerebral bioimaging and pathology.
Several large studies analyzed the risk factors for severe RSV disease in high-risk populations.
In terms of the methods used for IHC, large studies analyzed AR expression by IHC using TMA [ 9, 10], but this may have caused some bias due to the heterogeneity in each sample.
This study was part of a larger study analyzing the impact of personality and QoL on morbidity, mortality, and health care consumption in breast disease.
To address this directly in a clinical setting, the present large study analyzed the changes in CTC status, or CTC kinetics, occurring from baseline to completion of the first cycle of a new line of systemic therapy in patients with MBC.
Large-scale studies analyzing neurosurgical published research are lacking.
There have been no large prospective studies analyzing the diagnostic accuracy of MDCT in assessing treatment response in liver metastasis from breast cancer.
Despite this regional knowledge of echinoderms, there are surprisingly few large-scale studies analyzing echinoderm distribution and assemblage patterns.
