In the present study, larger responders to LPS inhalation were selected among a group of healthy subjects.
The entire study population, single or two vaccine doses, showed a similar pattern, with SpA patients on anti-TNF as monotherapy having a significantly larger responder proportion compared to the other treatment groups except for SpA on NSAIDs/analgesics (Chi2/Fisher's exact test; P between <0.001 and 0.033).
Analysis restricted to patients who fulfilled the Rome II criteria for irritable bowel syndrome showed larger responder rates for psyllium compared with placebo relative risk during the first month 1.81 (1.12 to 2.94) compared with 1.60 (1.13 to 2.26) for all patients with irritable bowel syndrome.
Alternatively some of the changes may be due to measurement error rather than a true change in participation, although repeatability investigations had suggested that most items on the KAP are not subject to large responder variations in short-term reporting [ 38].
Fractional decrease in FDG SULmax from baseline to post-cycle 1 imaging is significantly larger in responders than in non-responders, while change in FLT SULmax is not significantly different between these groups over the same period of time.
The increase in N-glycan sialylation was larger in responders than in non-responders during pregnancy (for IgG1: within responders +1.8%, SD 0.42%, P = 0.0007; within non-responders +0.34%, SD 0.42%, p < 0.216; for IgG2: within responders +1.8%, SD 0.50%, P = 0.0008; within non-responders +1.0%, SD 0.42%, P < 0.052).
With each of the investigated assessments and time points (TDI, SGRQ, and trough FEV1: Day 28, 84, and 168; CAT: Days 84 and 168), LS mean SOBDA change scores were statistically significantly larger in responders compared with non-responders, demonstrating the ability to measure less dyspnea with daily activities (p < 0.001 for all assessments and all time points; Fig. 1).
Using a composite index computed as the product of tidal volume by heart rate divided by respiratory rate, they observed that ΔPP was significantly larger in responders than in non-responders only in patients with above median values of this composite index.
The largest group of responders were in their 50s.
The largest group of responders were specialist registrars or consultants within the first decade of appointment (table 1).
