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The largest reported studies on complication rates in laparoscopy are based on gynecologic procedures.
As an example, the largest reported studies to date assessed only 164 (Murphy et al. 2005) and 216 (Naranjo et al. 2012) trees.
In this study we ran two, well statistically powered cohorts to allow independent analysis of each, while the combined analysis represents one of the largest reported studies to date for rodent depression models (22 FRL, 17 FSL).
Moreover, the National Surgical Adjuvant Breast and Bowel Project (NSABB) B-18, one of the largest reported studies including 1523 patients, has clearly shown that at 9 years of follow-up, the outcome of patients who received primary chemotherapy was equal to that for patients treated with adjuvant chemotherapy (Wolmark et al, 2001).
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This is the largest reported study reviewing frailty and the need for organ supports and outcomes in complex orthopaedic surgery.
Two large previously reported studies of knee OA have shown that both lumiracoxib and celecoxib were superior to placebo in terms of conventional outcome measures.
This approach of combining literature review with the largest newly reported study is a combination used often in biomarker research.
This study, nevertheless, has a number larger than most previously reported studies in such a population [ 7].
Overall, our findings were to a large degree consistent with previously reported studies.
In the largest reported venographic study, Geerts et al. [24] identified DVT in 58% of 349 trauma patients receiving no antithrombotic prophylaxis and undergoing contrast venography 1 3 weeks after admission.
This is the largest reported randomised study to date in this setting.
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