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The largest noncoding region (755 bp) of A. kona mtDNA also contains its largest repetitive region, which exhibits extensive predicted secondary structure (supplementary fig. S2, Supplementary Material online).
rDNA is not only a crucial gene for basic cellular functions but also forms the largest repetitive domain in the genome.
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In this small study, the MSIII proved to be highly resilient and able to maintain function even after large repetitive emboli.
Herein structural- and matrix proteins provide a great potential, but their large repetitive sequences pose a major challenge in their assembly.
Complexities in assembling such large repetitive regions have limited detailed studies of centromeric chromatin organization.
However, de novo sequencing of large repetitive eukaryotic genomes has yet to be accomplished with a NGS platform and remains an important and significant goal.
Future improvements in NGS technologies may continue to reduce the time and cost of such projects, but this strategy will likely always be valuable for addressing the complexities of sequencing large repetitive genomes with NGS.
Next generation sequencing technologies have brought about great improvements in sequencing throughput and cost, but do not yet allow for de novo sequencing of large repetitive genomes as found in most crop plants.
Hence, there may be a shift in the location of the strain concentration at the femoral enthesis from the inferior margin of the AM fibers during activities of daily living to that of the PL fibers during athletic activities that involve large repetitive internal tibial torques, such as soccer, football, basketball, and volleyball, among others.
The large repetitive interchromosomal duplications harbour an importin-4-like gene fragment.
The Y chromosome appears to have accumulated small and large repetitive interchromosomal duplications.
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