However, two large recently published randomized clinical trials, OSCAR [5] and OSCILLATE [6], failed to prove any clinical benefit when HFOV was applied in adults with moderate-to-severe ARDS as compared with a strategy with low tidal volume, high positive expiratory pressure (PEEP) and limited plateau pressure (Pplat).
A possible illustration for this scenario is four large, recently published GWA studies for type 2 diabetes [7] [10].
Our review is strengthened by the addition of two large recently published RCTs, including a total of 470 patients for analysis.
Finally, a large recently published retrospective study of US adults [ 24] was designed to examine HRQL based on both number and type of chronic conditions.
The Exeter study, and the large, recently published multi-centre HAPO study, showed that even in non-diabetic pregnancies, neonatal adiposity is positively related to maternal fasting glucose concentrations [ 17, 35].
The outpatient setting and the permanent nature of AF render the number of patients with hospitalizations and "unstable disease" in our cohort remarkable, especially when this number was compared to the markedly lower hospitalization rate (about 25 27%) in large, recently published trials in AF patients such as ADONIS/EURIDIS [ 29], ATHENA [ 10] and RACE II [ 32].
In contrast to our null findings, two large, recently published studies showed a positive association between PD and ER-negative cancers (Yaghjyan et al, 2011), and an association between PD and decreased ER expression (Heusinger et al, 2012), respectively, which could indirectly point to an association with the basal subtype.
On the other hand, in a large recently published study [ 32], only 0.7% of the IHC negative tumors were found to be positive by FISH and 5.9% IHC 3+ tumors were FISH negative so that there was a very good correlation between the HER-2/neu status assessed by FISH and IHC in 0, 1+ as well as 3+ tumors.
Thus, despite growing concern over the last years that treatment with DPP-4 inhibitors is associated with increased risk of pancreatitis and pancreatic cancer, two large recently published randomized controlled clinical trials demonstrated that treatment with saxagliptin and alogliptin is not associated with an increased risk of either adverse outcome [ 1, 2].
Many studies including large and recently published ones were excluded.
Nevertheless, considering studies in a large cohort recently published, PD is now considered as a feasible dialysis method for most PKD patients without higher risk of infectious or mechanical complications [ 8– 10].
