Exact(8)
We build a set of the rank sums rS Cq where r s C q = r a n k (b r a w q x ) + r a n k (c o v q x ) + r a n k (i d e n t i t y q x ) x ∈ C q. Finally, the best mixed-ranking score (BMS) for the query q is defined as the largest rank sum r in rS Cq, B M S q = max (r r ∈ r s c q ).
The largest rank is the intrinsic manifold dimension, while the number of components T is related to the manifold condition number.
A few patches of the largest rank are sometimes found, but their total area is statistically equivalent to that of one patch.
Essentially, the number of measurements should be greater than a constant times the largest rank among all of the D t plus the log of the number of components.
The characterized genes (Table 1) that showed the largest rank ratio changes in liver against mixed blood stages in P. yoelii were PY01852, a putative phosphotidylethanolamine binding protein; PY03168, the circumsporozoite protein; PY00446, a polyprenyl synthetase; PY00573 lipoamide dehydrogenase; and PY01586, beta-hydroxyacyl-acp dehydratase precursor.
For the Reduce task, the algorithm finds the largest rank value for the genes that will then be sorted.
We compared the rank of pathways before and after using the parasite genetic network, and extracted the ones with largest rank difference.
All test statistics with rank less than the test statistic with the largest rank for which the corrected value is less than the desired error rate (e.g., 0.05) are significant.
Related(2)
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com