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The multicenter European Pathway CH-1 study is the largest randomized, controlled neurostimulation study performed in CCH and confirms that patient-controlled electrical stimulation of the SPG is an effective treatment option for CCH sufferers with an acceptable safety profile.
The study will be the largest randomized, controlled trial yet to evaluate the effectiveness of robotic gait assist, but the "qualitative" aspect of it is also new.
This is the second but largest randomized controlled trial in which CGM is used to guide glycemic control in critically ill patients.
That survey, however, was conducted in October 1995, which was before the publication of the largest meta-analysis [ 1] and largest randomized controlled trial [ 2] to date.
Into this setting the current paper was published as the largest randomized, controlled, single-blinded trial to evaluate the issue [ 11].
Data from the largest randomized, controlled trial for the treatment of children hospitalized with severe malaria were used to identify such predictors of a poor outcome from severe malaria.
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A larger randomized controlled trial appears warranted in this participant population.
Much of the literature consists of pilot projects or case study designs although larger randomized controlled trails are now emerging.
Several large, randomized, controlled trials provide evidence that neoadjuvant chemotherapy improves the outcome of radical cystectomy for muscle invasive urothelial bladder cancer.
Patient outcomes after open abdominal aortic aneurysm and endovascular aortic aneurysm repair have been widely reported from several large, randomized, controlled trials.
The feasibility and acceptability of this intervention will be extensively evaluated with the explicit intent of informing a subsequent larger randomized controlled trial.
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