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Sacubitril/valsartan (LCZ696) is a first-in-class angiotensin receptor neprilysin inhibitor shown to reduce mortality and morbidity in the recently completed largest outcome trial in patients with HFrEF (PARADIGM-HF trial).
The largest outcome category is signs or symptoms reflecting the continuation or end of a medical condition (16%).
The largest outcome gain in terms of QALYs, 0.105, is estimated among women with a history of AH starting at age 35.
It is expected to report in 2018 and is currently the largest outcome trial ongoing involving SGLT-2 inhibitors and will be well powered to answer the question as to whether dapagliflozin could offer CV benefits, as well as addressing other safety-related questions.
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"If you do a large outcome study in 10,000 people in the same way you do short-term studies, you'll never finish," Dr. Temple said.
"If one of the focuses of this government is getting Aboriginal and Torres Strait Islander people employed and staying within the workforce then one would have thought we'd have seen a larger outcome of Aboriginal and Torres Strait Islander organisations funded under this strategy.
A large outcome trial of 9vHPV vaccine was conducted.
Many would rather not sell, and instead they roll the dice and hope for a larger outcome.
You want to control a large outcome; you don't want to control the intermediate steps.
But, the larger outcome of the episode is that we erected another fence of privacy between others and your personal data.
Finally, they presented a local search technique for query optimization that worked well with large outcome spaces.
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