In the era of structural genomics, comparing a large number of structures can be a dauntingly time-consuming task.
Given the challenges in structurally determining GPCRs and the large number of structures that remain to be solved, one approach to maintain the recently developed momentum is to prioritize those GPCRs with the highest likelihood of success.
Since the pair-wise structure comparison and distance estimation approach that we used for MFE structure predictions were not applicable to large number of structures we had to devise a new way to quantify the structural distance between the donor site and the branchpoint sequence.
Amongst structural materials, steel is characterised by its suitability to a large number of structures as well as a highly pollutant supply chain.
Praga, by contrast, still has the physical touch of history, with a large number of structures that survived World War II.
But, due to a large number of structures, a manual examination is usually impractical.
In VS experiments the large number of structures, which are often obtained from different sources, leads to additional problems.
A large number of structures and compositions occur between the initial supersaturated solid solution and the stable Mg2Si phase.
This infrastructure is aging, and a large number of structures will exceed the prescribed service period in the near future.
A large number of structures designed according to the most recent seismic regulation in Europe have been analysed.
