Such an adaptive landscape might favor the fixation of large mutations in order to move sufficiently close to an alternative adaptive peak to experience a fitness benefit.
Although the global assembly paradigm has the potential to detect larger mutations, in practice it is less sensitive and more time consuming because a large proportion of reads used for assembly are not from candidate indels.
(2) In Fig. 2b, the value of H has a larger mutation in the stone ballast area.
For BphQTLch4, one resistant IL-BPH carried a functional sesquiterpene synthase (STPS) gene located on the long arm of chromosome 4. STPS was up-regulated by BPH infestation in the IL-BPH but with no expression in infested KDML, which carries a large mutation in its promoter region (Kamolsukyunyong et al. 2013).
This mendelian proportion suggests that there are no deleterious effects for an heterozygous Large mutation in the Dmd mdx phenotype.
Out of the total 4219 halleri-origin and 4952 lyrata-origin disrupted genes, only 511 genes (2.5%) showed large-effect mutations in both homeologs in the same accession, suggesting that large-effect mutations in both homeologs were highly deleterious.
Our paper, "Biophysics of large-effect mutations in steroid hormone receptor evolution," with UO lab members Mike Harms and Geeta Eick as lead authors, was published in PNAS.
Harms MJ, Eick GN, Goswami D, Colucci JK, Griffin PR, Ortlund EA, Thornton JW. 2013) Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors.
All of these models propose that stress induces new large-effect mutations in nongrowing cells.
In summary, exonic, promoter, splice-site, and large deletion mutations in AIP are implicated in 31% of families in our FIPA cohort.
