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This beneficial effect among girls was particularly seen among the largest infants weighing 2.0 kg or more at inclusion.
The two largest infants born to mothers in the intervention arm (5.39 kg and 4.07 kg, with birthweight centiles ≥97.7 and birthweight standard deviation scores >3.5, fig 3) were born to mothers who withdrew from the intervention (included in the intention to treat analysis).
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The U.K. and the Netherlands are the two largest infant-nutrition markets for Numico in terms of sales.
This is the largest infant leukaemia study to date and included availability of MLL gene status.
We assumed that one of the largest infant studies, the Woodruff et al. study [ 30], would represent best the association between traffic-related fine particles and total mortality, even though they used PM10 as a surrogate for particulate air pollution.
Large infants may be an indication of actual or incipient maternal diabetes mellitus.
Mortality among newborn infants, for example, is highest when they are either very small or very large; infants of intermediate size have a greater chance of surviving.
Overweight and obese women in our sample preferred larger infants which has been previously reported[ 11].
This is most likely explained based on the high incidence of large infants in this group.
Women who were randomised to the high glycaemic diet delivered larger infants that were both heavier and larger in size.
These larger infants were likely to have lower transfusion thresholds as they were less ill and probably more anaemic.
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