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Chrysler was the only one of the Detroit companies to lose money in 2010 — $652 million — but it has since repaid $7.5 billion in high-interest government loans that were its largest hindrance to profitability.
A three-way analysis of variance (ANOVA) of the results was conducted and it showed that micro-motion presents the largest hindrance to bone formation during healing.
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One of the largest hindrances to identifying particular pathways affected by the drug is the high number of hypothetical proteins that show changes.
The largest hindrances to protein identification by mass spectrometry are sample complexity and dynamic range.
Ironically, yet fittingly, the fact that Google owns YouTube has proven to be a larger hindrance to technology companies than media companies.
Patient motivation/interest Many researchers felt that a large hindrance to recruitment came from a lack of patient motivation to comply with an unappealing intervention.
This proved to be a large hindrance in several areas, as the South Vietnamese government had a policy of having majority ownership of any industry deemed to be of vital national importance, as well as banning foreigners from having a stake in such ventures.
Furthermore, complex 6 was demonstrated evaporable, owing to the electrostatic interaction strongly reduced by its anion with the largest steric hindrance and well-dispersed charges.
This fact can be explained by the large steric hindrance arising from the large aromatic ensembles, including one central biphenyl group and two symmetric naphthenic groups[29].
Reaction of CH[3,5-Pz(CO2H 2]3 with (Ph3Sn 2O yielded hexanuclear triphenyltin polycarboxylate CH[3,5-Pz(CO2SnPh3)2]3, which did not assemble into a supramolecular architecture like those in complex 1 or 2, possibly owing to the relatively large steric hindrance of the phenyl groups as well as the relatively large size of the hexabasic carboxylic acid.
Phenyl groups feature larger steric hindrance, but they ensure stability and high chemical inertness.
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