The four groups represent the GC content closest to 0.5 and those at which 64×4 NBDM delivers the largest overall plain mutability advantage relative to 4×4 mutation (0.55), the largest disadvantage (0.42), and 2nd-largest low-GC advantage (0.34).
On the other hand, the largest disadvantage of the architecture is the massive size of calculation tasks that compare terribly to the computational power of today's processors.
Their largest disadvantage was the successful large-scale UN interdiction effort, as North Korean supplies and supply lines were subjected to UN bombing raids.
While this approach is quite inexpensive, with the 2004 field survey described here costing approximately US$7,000, the largest disadvantage is undoubtedly the necessity conduct human landing catches and exposes participants to increased malaria transmission hazard [ 22].
"A vicious cycle may ensue," wrote Professor Autor and his co-author, Melanie Wasserman, a graduate student, "with the poor economic prospects of less educated males creating differentially large disadvantages for their sons, thus potentially reinforcing the development of the gender gap in the next generation".
Nuclear energy possesses large disadvantages, among which waste, proliferation and safety.
Direct seeding of Koshihikari has been tried, but it has large disadvantages because it produces long culms and a higher lodging rate (Sakai et al. 2000, Sato and Sakai 2004).
As Germany is known for a highly credentialist labour market, we expected dropouts without pre-tertiary vocational qualifications to have large disadvantages in the labour market transitions, compared to job-seekers with pre-tertiary vocational qualifications.
There were almost no differences by sex, whereas all indicators showed large disadvantages among elderly individuals.
