Therefore, on one hand our functional analysis does not support low cell cycle activity in PAR but, rather, a larger cell cycle activity compared with MFP.
This has made S. pombe currently the organism with the largest amount of cell cycle transcriptome data.
As expected, the largest network implicated cell cycle functions; however, we also noticed a multinode network and several singleton nodes representing G protein coupled receptor (GPCR -mediated transmembrane siGPCR -mediated
This extra information allows us to detect a larger number of cell cycle oscillating genes.
Considering the seven periodic classes together, one notes a large number of "cell cycle" (GO 0007049) annotations.
A large number of cell cycle regulatory genes are also principal targets of p53-mediated repression (38, 39).
A larger number of cell cycle control genes were expressed late including cyclins, cyclin-dependent kinases and CDCs, with more expressed after carboplatin paclitaxel treatment.
Herein, in agreement with experimental results, we have shown that the time for reaching a steady expression rate is much larger than the cell cycle duration (see [ 10]).
The UPS controls a large number of cell cycle proteins such as p27, Rb, cyclin D1, p53, the Bcl-2 family members, and NF κB signaling [ 174, 175].
Thus, our data suggest that the reductions in BRCA1 and RAD51 foci were not due to large differences in cell cycle distribution, nor checkpoint activation, and that cell cycle control was not significantly impacted by mutation of MTPAP.
