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The size of individual HTLV-1 particles was determined by measuring an averaged diameter in the section (through the 3D object) of largest appearance of the particle.
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True, some have expressed that concern, however Mr. Longi's commentary totally ignores the fact that almost all of the objections were to the relatively huge size and large appearance of his proposal.
We have amended the text to clarify that the large appearance of the foramen of Magendi and fourth ventricle and large subcerebellar cistern are as a consequence of vermis hypoplasia, making these spaces appear larger: "As a consequence of these abnormalities, fluid-filled spaces surrounding the cerebellum appeared larger.
It was also noted that there was a striking clustering of these multilamellar structures (Fig. 3D), and this likely accounts for the larger appearance of the LAMP1 immunolabelling in AP-5-deficient fibroblasts (Fig. 2A) and the increase in the area of LAMP1 puncta quantified for the p.Q578* line on the automated microscope (Fig. 2C).
This cell preparation was found to be close to 100% notochordal in content, recognized by the classic physaliferous, large vacuolated appearance of the cells.
A large fractional appearance of a reaction does not only indicate its increased utilization, but also the activation of related processes, which result in an increased contribution of this reaction to the overall number of EFMs.
Serosal and amniotic cells are readily distinguished throughout these events by their nuclei: the larger, brighter appearance of the serosal nuclei is consistent with their high degree of polyploidy (Fig. 2A,C1,C2) (Truckenbrodt, 1973).
The large size and appearance of the masses have not been reported before in a patient with isolated influenza.
The authors also describe endocytic events, which are defined as shallow invaginations with diameters larger than SVs, and the subsequent appearance of larger diameter vesicles.
RVF outbreaks are associated with persistent heavy rainfall, sustained flooding and appearance of large numbers of mosquitoes, the main vector.
For example, Meyer presents a chart on page thirty-five of "Darwin's Doubt" that appears to show the sudden appearance of large numbers of major animal groups in the Cambrian: the smoking gun.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com