These studies require validation in larger, adequately powered trials.
The observed promising role as a tool to prevent VAP needs to be confirmed in a larger, adequately powered, randomized trial.
The role of routine early PCI after fibrinolysis, using stents and contemporary pharmacotherapy, has not been studied in a large adequately powered randomized trial.
However, larger, adequately planned studies are needed to confirm the role of PPIs in the management of GERD-related asthma and chronic cough.
Previous evidence suggests that acute treatment with statins reduce atherosclerotic complications, including periprocedural myocardial infarction, but currently, there are no large, adequately powered studies to define the effects of early, high-dose statins in patients with acute coronary syndrome (ACS) and planned invasive management.
The field's understanding of CD etiology will benefit from larger, adequately powered studies in gene identification efforts; the incorporation of polygenic approaches in gene-environment interplay studies; attention to the mechanisms of risk from genes to brain to behavior; and the use of genetically informative data to test quasi-causal hypotheses about purported risk factors.
Importantly, the anti-cancer efficacy of different radioiodine activities has not been addressed in large, adequately powered controlled clinical trials.
The findings of this pilot study warrant larger, adequately powered controlled trials to test the efficacy of prescribed moderate aerobic exercise as a component of cannabis dependence treatment.
Large adequately powered RCTs comparing ranibizumab, bevacizumab, aflibercept and triamcinolone are needed.
A substantially larger, adequately powered study is therefore warranted before these results can be generalized.
